The Expression of GPR30 in Iron-Overloaded Atypical Ovarian Epithelium and Ectopic Endometrium Is Closely Correlated with Transferrin Receptor and Pi3K

Figure 4

Ferric iron (blue) deposits of ovaries with Prussian blue staining in the endometriosis model group (b) by repeated injections of iron, with most of the iron (Fe⁺²) accumulated in macrophages. There were no ferric iron deposits identified in control ovary tissue (a). Repeated microinjections of iron led to different morphologic changes in the ovarian epithelium: multinucleated giant cells (d), epithelial hyperplasia (e), and papillary hyperplasia with atypical cells (f) in iron-dextrin-injected ovaries. Image (c) is control ovary tissue injected with glucose water. No cellular morphology changes were observed in the control ovary tissues, which clearly indicate that the tissue reaction observed was not induced by surgical trauma or dextrin as an iron carrier substance.

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