Proanthocyanidins Activate Nrf2/ARE Signaling Pathway in Intestinal Epithelial Cells by Inhibiting the Ubiquitinated Degradation of Nrf2

<div>Localization of the Nrf2 protein and ARE gene activity in MODE-K cells with PC-induced concentrations and time gradients. (a) Cells were treated with 0, 1, 2.5, and 5 <i>μ</i>g/mL PC for 24 h (40x). (b) Cells were treated with 5 <i>μ</i>g/mL PC for 0, 3, 6, 12, and 24 h (40x). (c) Effects of PC on ARE gene activity in MODE-K cells. 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BioMed Research International

fig2

Figure 2

Figure 2: Proanthocyanidins Activate Nrf2/ARE Signaling Pathway in Intestinal Epithelial Cells by Inhibiting the Ubiquitinated Degradation of Nrf2 