Research Article

Systematic Characterization of Expression Patterns and Immunocorrelations of Formin-Like Genes in Breast Cancer

Table 1

GO and KEGG pathway enrichment analyses of FMNL1 in BRCA.

TermDescriptionSizeNESFDR

Biological process
 GO:0045730Respiratory burst271.5240.005
 GO:0071887Leukocyte apoptotic process1031.4880.005
 GO:0050867Positive regulation of cell activation2981.4900.005
 GO:0032633Interleukin-4 production341.5040.005
 GO:0045576Mast cell activation581.5020.005
Cell component
 GO:0042611MHC protein complex191.581<0.001
 GO:0001772Immunological synapse321.558<0.001
 GO:0071782Endoplasmic reticulum tubular network18-2.144<0.001
 GO:0042629Mast cell granule211.5030.001
 GO:0098636Protein complex involved in cell adhesion351.5170.001
Molecular function
 GO:0042287MHC protein binding241.563<0.001
 GO:0003823Antigen binding521.536<0.001
 GO:0016502Nucleotide receptor activity221.4950.011
 GO:0004896Cytokine receptor activity881.4760.012
 GO:0038187Pattern recognition receptor activity201.4770.015
KEGG
 hsa05332Graft-versus-host disease371.616<0.001
 hsa05320Autoimmune thyroid disease501.608<0.001
 hsa05330Allograft rejection351.591<0.001
 hsa04940Type I diabetes mellitus411.588<0.001
 hsa05150Staphylococcus aureus infection521.584<0.001

Note: NES: normalized enrichment score.