Systematic Characterization of Expression Patterns and Immunocorrelations of Formin-Like Genes in Breast Cancer

Table 4

The correlation between FMNL and immune cell biomarkers.

Description	Gene marker	FMNL1		FMNL2		FMNL3
		Correlation	value	Correlation	value	Correlation	value
CD8+ T cell	CD8A	0.714	<0.001	0.397	<0.001	0.468	<0.001
	CD8B	0.663	<0.001	0.378	<0.001	0.355	<0.001
T cell (general)	CD3D	0.760	<0.001	0.373	<0.001	0.408	<0.001
	CD3E	0.759	<0.001	0.402	<0.001	0.460	<0.001
	CD2	0.762	<0.001	0.437	<0.001	0.466	<0.001
B cell	CD19	0.609	<0.001	0.280	<0.001	0.293	<0.001
	CD79A	0.595	<0.001	0.315	<0.001	0.327	<0.001
Monocyte	CD86	0.765	<0.001	0.566	<0.001	0.536	<0.001
	CSF1R	0.773	<0.001	0.479	<0.001	0.664	<0.001
TAM	CCL2	0.569	<0.001	0.446	<0.001	0.353	<0.001
	CD68	0.695	<0.001	0.493	<0.001	0.521	<0.001
	IL10	0.634	<0.001	0.491	<0.001	0.478	<0.001
M1 macrophage	NOS2	0.111	<0.001	0.286	<0.001	0.397	<0.001
	IRF5	0.589	<0.001	0.274	<0.001	0.333	<0.001
	PTGS2	0.293	<0.001	0.466	<0.001	0.395	<0.001
M2 macrophage	CD163	0.637	<0.001	0.545	0.000	0.462	<0.001
	VSIG4	0.545	<0.001	0.424	<0.001	0.429	<0.001
	MS4A4A	0.645	<0.001	0.528	<0.001	0.524	<0.001
Neutrophils	CEACAM8	0.015	0.624	0.090	0.003	0.015	0.630
	ITGAM	0.667	<0.001	0.399	<0.001	0.523	<0.001
	CCR7	0.692	<0.001	0.314	<0.001	0.414	<0.001
Natural killer cell	KIR2DL1	0.385	<0.001	0.278	<0.001	0.187	<0.001
	KIR2DL3	0.395	<0.001	0.265	<0.001	0.200	<0.001
	KIR2DL4	0.487	<0.001	0.346	<0.001	0.121	<0.001
	KIR3DL1	0.468	<0.001	0.320	<0.001	0.274	<0.001
	KIR3DL2	0.508	<0.001	0.309	<0.001	0.228	<0.001
	KIR3DL3	0.272	<0.001	0.176	<0.001	0.096	0.001
	KIR2DS4	0.356	<0.001	0.255	0.000	0.168	<0.001
Dendritic cell	HLA-DPB1	0.818	<0.001	0.314	<0.001	0.528	<0.001
	HLA-DQB1	0.666	<0.001	0.298	<0.001	0.363	<0.001
	HLA-DRA	0.784	<0.001	0.477	<0.001	0.571	<0.001
	HLA-DPA1	0.770	<0.001	0.429	<0.001	0.584	<0.001
	CD1C	0.583	<0.001	0.232	<0.001	0.498	<0.001
	NRP1	0.290	<0.001	0.448	<0.001	0.723	<0.001
	ITGAX	0.797	<0.001	0.509	<0.001	0.598	<0.001
Th1 cell	TBX21	0.759	<0.001	0.420	<0.001	0.432	<0.001
	STAT4	0.715	<0.001	0.479	<0.001	0.547	<0.001
	STAT1	0.450	<0.001	0.458	<0.001	0.304	<0.001
	IFNG	0.613	<0.001	0.432	<0.001	0.291	<0.001
	TNF	0.456	<0.001	0.334	<0.001	0.210	<0.001
Th2 cell	GATA3	0.242	<0.001	0.483	<0.001	0.024	0.426
	STAT6	0.216	<0.001	0.024	0.425	0.352	<0.001
	STAT5A	0.475	<0.001	0.257	<0.001	0.413	<0.001
	IL13	0.309	<0.001	0.257	<0.001	0.150	<0.001
Tfh cell	BCL6	0.145	<0.001	0.183	<0.001	0.301	<0.001
	IL21	0.429	<0.001	0.340	<0.001	0.250	<0.001
Th17 cell	STAT3	0.193	<0.001	0.292	<0.001	0.384	<0.001
	IL17A	0.239	<0.001	0.229	<0.001	0.102	0.001
Treg cell	FOXP3	0.682	<0.001	0.469	<0.001	0.422	<0.001
	CCR8	0.567	<0.001	0.513	<0.001	0.469	<0.001
	STAT5B	0.204	<0.001	0.164	<0.001	0.444	<0.001
	TGFB1	0.559	<0.001	0.189	<0.001	0.622	<0.001
Exhausted T cell	PDCD1	0.758	<0.001	0.354	0.000	0.319	<0.001
	CTLA4	0.702	<0.001	0.496	<0.001	0.343	<0.001
	LAG3	0.613	<0.001	0.349	<0.001	0.130	<0.001
	HAVCR2	0.705	<0.001	0.521	<0.001	0.569	<0.001
	GZMB	0.641	<0.001	0.439	<0.001	0.229	<0.001

PS: the italic characters are negatively correlated.