Neutrophil-to-Lymphocyte Ratio and Early Neurological Deterioration in Stroke Patients: A Systematic Review and Meta-Analysis

Table 1

General characteristics of included studies.

First author	Year	Country	Type of stroke	Ethnicity	Design	END definition	END group		Non-END group		NOS score
								NLR		NLR
Lattanzi et al. [19]	2017	Italy	Hemorrhagic	Caucasian	R	(1) An on the NIHSS score, (2) a on GCS, or (3) death occurred from the time of admission to 7 days posthemorrhage	54		138		8
Qi et al. [22]	2018	China	Hemorrhagic	East Asian	R	(1) An on the NIHSS score, (2) a on GCS, or (3) death occurred from the time of admission to 7 days posthemorrhage	166		392		7
Nam et al. [21]	2019	Korea	Ischemic	East Asian	R	An on the total NIHSS score or ≥1 on the motor NIHSS score within the first 72 hours of admission	63		286		7
Chen et al. [15]	2020	China	Ischemic	East Asian	R	(1) An increase in from baseline or (2) an increase in Ia of within 72 h	77		180		7
Cong and Ma [16]	2021	China	Ischemic	East Asian	R	(1) An points in the total NIHSS score compared to the score at admission, (2) an point in the NIHSS specificity subitems, namely, level of consciousness (1a–1c) or motor capacity (5a–6b), or (3) new neurological deficits despite no change in the NIHSS score	55		74		8
Ferro et al. [17]	2021	Portugal	Ischemic	Caucasian	R	An increase in NIHSS at 24 hours from the baseline	85		240		8
Gong et al. [18]	2021	China	Ischemic	East Asian	R	An increase in the NIHSS score by ≥4 points in the total score within 24 h after thrombolysis	193		469		7
Mohamed et al. [20]	2021	Egypt	Hemorrhagic	Caucasian	P	(1) An on the NIHSS score, (2) a on GCS, or (3) death occurred from the time of admission to 7 days posthemorrhage	17		63		8
Zhi and Xiaopeng [23]	2021	China	Ischemic	East Asian	R	An on the total NIHSS score or ≥1 on the motor NIHSS score within the first 72 hours of admission	32		140		5

R: retrospective; P: prospective; : number; SD: standard deviation; NLR: neutrophil to lymphocyte ratio; NOS: Newcastle-Ottawa scale.