[Retracted] Deleterious Effects of Amoxicillin on Immune System and Haematobiochemical Parameters of a Rabbit

Table 7

Severity of different histopathological changes in organs of rabbits exposed to variable doses of amoxicillin.

Histopathological lesions	Groups/treatments
	A (100 mg/kg)	B (150 mg/kg)	C (200 mg/kg)
Liver
Karyorrhexis	+	++	++++
Congestion of central vein	−	−	+++
Cytoplasmic vacuolation	++	+++	++++
Disorganized hepatic cord	−	++	+++
Bile duct hyperplasia	+	+	+++
Necrosis and hydropic changes in hepatocytes	+	+++	+++
Pyknosis	+	++	++++
Vacuolar degeneration	++	++++	++++
Hemorrhages	+	++	+++
Ceroid formation	++	++	+++
Nuclear hypertrophy	++	++	++++
Congestion	++	+++	+++
Degeneration of hepatocyte	++	+++	++++
Kidney
Increased Bowman’s space	+	++	++++
Congestion	+	++	+++
Necrosis of renal tubular epithelial cell	+	++++	++++
Nuclear hypertrophy	+	+++	++++
Necrosis of renal tubules	+	+++	+++
Degeneration of renal tubule	+	+++	+++
Degenerative changes in kidney glomerulus	+	++	+++
Widening urinary space	+	+++	+++
Hemorrhage b/w tubule	+	+	++
Cell infiltration with pyknotic nuclei	+	++	+++
Heart
Necrosis of cardiac cells	+	+++	++++
Cytoplasmic vacuolization	++	+++	++++
Congestion	+	+++	++++
Neutrophilic myocarditis	+	+++	++++
Myofibrillolysis	+	+++	++++
Pyknotic nuclei	+	++	+++

Normal: −; mild: +; moderate: ++; severe: +++; very severe: ++++.