Development and Verification of Prognostic Nomogram for Penile Cancer Based on the SEER Database

Table 1

Characteristics of 1643 patients suffered penile cancer in SEER¹ database.

Factors	Total	%	Development group	%	Validation group	%
Age
50	176	10.7	126	10.9	50	10.2
50-59	272	16.6	180	15.6	92	18.7
60-69	418	25.4	291	25.3	127	25.8
70-79	413	25.1	300	26.1	113	22.9
80	364	22.2	254	22.1	110	22.4
Race
Black	167	10.2	123	10.7	44	9.0
White	1393	84.8	965	83.8	428	87.0
Others^2	83	5.0	63	5.5	20	4.0
Marital_status
Never married	315	19.2	227	19.7	88	17.9
Single^3	345	21.0	238	20.7	107	21.7
Married	983	59.8	686	59.6	297	60.4
Stage_T
Stage_Tx	40	2.4	34	3.0	6	1.2
Stage_T1a	427	26.1	292	25.4	135	27.4
Stage_T1b	153	9.3	110	9.5	43	8.7
Stage_T1NOS	331	20.1	227	19.7	104	21.1
Stage_T2	380	23.1	270	23.4	110	22.4
Stage_T3	269	16.4	184	16.0	85	17.3
Stage_T4	43	2.6	34	3.0	9	1.9
Stage_N
Stage_Nx	59	3.6	44	3.8	15	3.0
Stage_N0	1276	77.6	889	77.2	387	78.7
Stage_N1	92	5.6	61	5.3	31	6.3
Stage_N2	103	6.3	70	6.1	33	6.7
Stage_N3	113	6.9	87	7.6	26	5.3
Stage_M
Stage_M0	1584	96.4	1117	97.0	467	94.9
Stage_M1	59	3.6	34	3.0	25	5.1
Primary_site
Penis NOS	745	45.3	527	45.8	218	44.3
Prepuce	191	11.6	132	11.5	59	12.0
Glans	543	33.1	378	32.8	165	33.5
Body	88	5.4	58	5.0	30	6.1
Overlapping	76	4.6	56	4.9	20	4.1
Surgery^4
No	133	8.1	90	7.8	43	8.7
Destruction^5	8	0.5	5	0.4	3	0.6
Excision^6	454	27.6	315	27.4	139	28.3
Partial remove^7	802	48.8	558	48.6	244	49.6
Total remove^8	190	11.6	137	11.9	53	10.8
Radical surgery	52	3.2	42	3.6	10	2.0
Debulking surgery	4	0.2	4	0.3	0	0.0
Surgery_LN^9
No	1320	80.3	923	80.2	397	80.7
1-3	51	3.1	37	3.2	14	2.8
4	272	16.6	191	16.6	81	16.5
Radiation
No	1532	93.3	1071	93.0	461	93.7
Before^10	4	0.2	2	0.2	2	0.4
After^11	107	6.5	78	6.8	29	5.9
Chemotherapy
No	1445	87.9	1010	87.7	435	88.4
Yes	198	12.1	141	12.3	57	11.6
Histologic_type^12
805^13	74	4.5	55	4.8	19	3.9
807^14	1522	92.6	1062	92.2	460	93.5
808^15	47	2.9	34	3.0	13	2.6
Endpoint
Death	636	38.7	456	39.6	180	36.6
Cancer-specific death	250	15.2	175	15.2	75	15.2

¹The Surveillance, Epidemiology, and End Results Program; ²includes patients whose race were not black or white; ³includes patients who are divorced, separated, windowed, and unmarried but have domestic partner; ⁴the surgery of the primary tumor; ⁵local tumor destruction, includes electrocautery, fulguration, or laser; ⁶local tumor excision, includes excisional biopsy, electrocautery, cryosurgery, and laser ablation; ⁷simple/partial surgical removal of primary site; ⁸total surgical removal of primary site (enucleation); ⁹number of lymph nodes removed in surgery; ¹⁰radiation before surgery; ¹¹radiation after surgery; ¹²based on the 3rd Edition (ICD-O-3); ¹³includes verrucous papilloma, verrucous carcinoma, squamous cell papilloma, and papillary squamous cell carcinoma (8051, 8052); ¹⁴includes squamous cell carcinomas (8070-8076); ¹⁵includes Bowen disease, basaloid squamous cell carcinoma, and squamous cell carcinoma (clear cell type) (8081, 8083, 8084).