Development and Verification of Prognostic Nomogram for Penile Cancer Based on the SEER Database

Table 3

Univariate and multivariate Cox analyses for CSS based on penile cancer patients in development group.

Factors	Univariate analyses				Multivariate analyses
	HR^1	Lower.95	Upper.95	value	HR^1	Lower.95	Upper.95	value
Age (<50 reference)
50-59	0.8476	0.4903	1.465	0.554	0.8811	0.49409	1.5713	0.668058
60-69	0.7652	0.4621	1.267	0.299	0.7978	0.46209	1.3774	0.417553
70-79	0.7827	0.4717	1.299	0.343	1.029	0.58620	1.8046	0.921902
80	0.9276	0.5495	1.566	0.778	1.429	0.79779	2.5583	0.230137
Race (black reference)
White	0.8822	0.5529	1.408	0.599	0.7507	0.45865	1.2287	0.254011
Others^2	0.7126	0.3139	1.618	0.418	0.5988	0.25787	1.3906	0.232906
Marital_status (never married reference)
Single^3	0.7441	0.4810	1.1512	0.18431	0.7858	0.47988	1.2868	0.338117
Married	0.6157	0.4324	0.8767	0.00714	0.6577	0.44485	0.9724	0.035695
Stage_T (stage_Tx reference)
Stage_T1a	0.2181	0.10326	0.4606	6.55-05	0.7957	0.31850	1.9879	0.624708
Stage_T1b	0.4171	0.18737	0.9286	0.0322	1.151	0.44511	2.9769	0.771597
Stage_T1NOS	0.1487	0.06422	0.3442	8.56-06	0.4869	0.18971	1.2497	0.134547
Stage_T2	0.5935	0.30062	1.1717	0.1328	1.175	0.50536	2.7308	0.708256
Stage_T3	1.0107	0.51361	1.9887	0.9755	1.530	0.65305	3.5829	0.327708
Stage_T4	1.9844	0.89128	4.4184	0.0933	2.175	0.87897	5.3800	0.092794
Stage_N (stage_Nx reference)
Stage_N0	0.2941	0.1568	0.5517	0.000138	0.3897	0.19447	0.7808	0.007870
Stage_N1	0.9554	0.4387	2.0807	0.908571	0.7665	0.31698	1.8533	0.554915
Stage_N2	1.4215	0.6961	2.9028	0.334280	0.9938	0.43808	2.2543	0.988048
Stage_N3	2.2364	1.1506	4.3469	0.017615	1.575	0.71318	3.4777	0.261155
Stage_M (stage_M0 reference)
Stage_M1	11.5	7.289	18.13	<2-16	2.72	1.57625	4.6935	0.000325
Primary_site (penis NOS reference)
Prepuce	0.4812	0.2491	0.9296	0.0295	1.036	0.51798	2.0727	0.920041
Glans	1.2063	0.8702	1.6722	0.2604	1.026	0.71082	1.4806	0.891476
Body	1.0869	0.5452	2.1672	0.8128	0.918	0.44012	1.9150	0.819678
Overlapping	1.4768	0.7853	2.7773	0.2263	1.375	0.70899	2.6685	0.345756
Surgery^4 (no reference)
Destruction^5	0.4711	0.06416	3.4594	0.4594	1.149	0.14605	9.0462	0.894733
Excision^6	0.0860	0.04387	0.1686	9.03-13	0.2622	0.11916	0.5770	0.000879
Partial remove^7	0.3971	0.26150	0.6029	1.46-05	0.6501	0.36843	1.1472	0.137283
Total remove^8	0.5274	0.31219	0.8910	0.0168	0.8146	0.42677	1.5549	0.534119
Radical surgery	0.9327	0.48473	1.7946	0.8346	1.326	0.61167	2.8763	0.474444
Debulking surgery	0.4784	0.06511	3.5149	0.4687	0.3596	0.04589	2.8182	0.330242
Surgery_LN^9 (no reference)
1-3	3.219	1.8514	5.596	3.43-05	1.326+00	0.68914	2.5514	0.398109
4	1.438	0.9993	2.069	0.0504	6.195-01	0.39521	0.9712	0.036836
Radiation (no reference)
Before^10	2.264-06	0.000	Inf	0.992236	6.685-06	0.00000	Inf	0.992907
After^11	2.364	1.525	3.666	0.000121	7.886-01	0.46332	1.3421	0.381292
Chemotherapy (no reference)
Yes	3.704	2.686	5.108	1.41-15	1.525+00	0.98840	2.3538	0.056489
Histologic_type^12 (no reference)
807^13	3.343	1.0673	10.47	0.0383	2.655+00	0.81747	8.6243	0.104237
808^14	3.749	0.9373	15.00	0.0617	4.403+00	1.04301	18.5875	0.043667

Signif. codes: 0 “” 0.001 “” 0.01 “” 0.05 “.” 0.1 “”. 1; Inf: infinity. ¹Hazard ratio; ²included patients who were not black or white; ³includes patients who are divorced, separated, windowed, and unmarried but have domestic partner; ⁴the surgery of the primary tumor; ⁵local tumor destruction, includes electrocautery, fulguration, or laser; ⁶local tumor excision, includes excisional biopsy, electrocautery, cryosurgery, and laser ablation; ⁷simple/partial surgical removal of primary site; ⁸total surgical removal of primary site (enucleation); ⁹number of lymph nodes removed in surgery; ¹⁰radiation before surgery; ¹¹radiation after surgery; ¹²based on the 3rd Edition (ICD-O-3); ¹³includes squamous cell carcinomas (8070-8076); ¹⁴includes Bowen disease, basaloid squamous cell carcinoma, and squamous cell carcinoma (clear cell type) (8081, 8083, 8084).