Neuroprotective Effect of Polyherbal Recipe Containing Ginger, Chinese Date, and Wood Ear Mushroom against Ischemic Stroke with Metabolic Syndrome Condition via Epigenetic Modification of Inflammation and Oxidative Stress

Figure 6

Effects of the polyherbal recipe containing ginger, Chinese date, and wood ear mushroom (GCJ) at the doses of 100, 200, and 300 mg/kg BW on the cortical expressions of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). (a) Representative bands of IL-6, TNF-α, DNMT1, and HDAC3 from the cerebral cortex of various treatment groups. Statistical data from the western blot analysis for the cortical expression of (b) IL-6, (c) TNF-α, (d) DNMT1, and (e) HDAC3. Data were expressed as (/group). ^A,AA,AAA value < 0.05, 0.01, and 0.001, respectively, compared to ND+vehicle; ^B value < 0.05, compared to HCHF+sham+vehicle; value < 0.05, 0.01, and 0.001, respectively, compared to HCHF+MCAO+vehicle.

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