SOX8 Knockdown Overcomes Enzalutamide Resistance in Castration-Resistant Prostate Cancer by Inhibiting the Notch Signaling Pathway

Figure 1

The expression of SOX8, Notch4, and Hes5 in samples of prostate cancer (PCa) and castration-resistant prostate cancer (CRPC) and the Kaplan-Meier survival analysis for the progression-free survival (PFS) of 35 patients with CRPC. (a–c) The expression levels of SOX8, Notch4, and Hes5 were detected by immunohistochemistry (×200). (d–f) Average staining scores for SOX8, Notch4, and Hes5 in PCa and CRPC samples. According to staining intensity, samples were divided as follows: 0, no staining; 1, weak staining; 2, light staining; 3, moderate staining; and 4, strong staining. Staining were defined as having a negative expression, while staining scores of ≥2 were defined as having a positive expression. (g, h) The correlation curve between SOX8 staining scores versus Notch4 or Hes5 staining scores in CRPC tissues. (i–k) Kaplan-Meier survival analysis was used to assess the relationship between PFS and the expression of SOX8, Notch4, and Hes5 in patients with CRPC. was considered to be statistically different.