Research Article
SOX8 Knockdown Overcomes Enzalutamide Resistance in Castration-Resistant Prostate Cancer by Inhibiting the Notch Signaling Pathway
Figure 7
Knocking down SOX8 and/or treatment with RO04929097 suppress the growth and bone metastasis of Enza-R cells in vivo. Nude mice with subcutaneous or bone xenograft tumors were treated with 10 mg/kg enzalutamide and 50 mg/kg RO04929097. (a) Tumor growth curve. (b) Weight of tumors. (c) Images of the recovered tumors. (d) X-ray of bone metastasis (red arrow). (e) H&E staining of bone metastasis (upper ×100, lower ×200; black arrow). (f) The expression of SOX8 and Notch4 in xenograft and bone lesion was detected by IHC. ; ; Enza-R: enzalutamide-resistant LNCaP cells.
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