Association of PTPRT Mutations with Cancer Metastasis in Multiple Cancer Types

Figure 6

The potential mechanism of PTPRT underlying cancer metastasis. PTPRT mutations or hypermethylation of the promoter region leads to gene dysfunction, which in turn affects adhesion and aggregation between cells and leads to tumor invasion/migration and metastasis. On the other hand, the dysfunction of PTPRT activates the STAT3 pathway, which promotes the gene transcription and leads to cell survival, proliferation, migration, and metastasis.