[Retracted] Might Patients with Metastatic Gastrointestinal Stromal Tumors Benefit from Operative Management? A Population-Based Retrospective Study
Table 4
Association between surgery and OS and GSS among non-metastatic GIST patients in the SEER dataseta.
Resection (no vs. yes)
GSS
OS
Crude
Adjusted
Crude
Adjusted
HR (95% CI)
value
HR (95% CI)
value
HR (95% CI)
value
HR (95% CI)
value
Chemotherapy
Yes
2.16 (1.76-2.64)
<0.001
2.39 (1.93-2.97)
<0.001
2.17 (1.80-2.64)
<0.001
2.37 (1.93-2.91)
<0.001
No/unknown
2.55 (1.88-3.45)
<0.001
3.13 (2.26-4.32)
<0.001
2.29 (1.73-3.03)
<0.001
2.65 (1.97-3.56)
<0.001
Age at diagnosis, y
2.12 (1.79-250)
<0.001
2.60 (2.17-3.12)
<0.001
2.03 (1.73-2.37)
<0.001
2.44 (2.06-2.89)
<0.001
Marital status
Married
2.42 (1.93-3.03)
<0.001
2.86 (2.23-3.66)
<0.001
2.36 (1.90-2.93)
<0.001
2.74 (2.16-3.47)
<0.001
Unmarried
1.76 (1.37-2.27)
<0.001
2.23 (1.70-2.94)
<0.001
1.69 (1.34-2.13)
<0.001
2.10 (1.63-2.70)
<0.001
Tumor site
Stomach
2.36 (1.84-3.02)
<0.001
2.71 (2.08-3.54)
<0.001
2.21 (1.75-2.78)
<0.001
2.53 (1.98-3.24)
<0.001
Small intestine
1.51 (1.01-2.26)
0.043
1.84 (1.18-2.86)
0.007
1.51 (1.03-2.20)
0.033
1.79 (1.18-2.71)
0.006
Other digestive organs
1.69 (1.08-2.62)
0.021
1.96 (1.18-3.25)
0.009
1.62 (1.06-2.46)
0.025
1.78 (1.11-2.87)
0.017
Non-digestive organs
2.12 (1.22-3.69)
0.008
2.37 (1.26-4.45)
0.007
2.15 (1.30-3.55)
0.003
2.39 (1.35-4.26)
0.003
Tumor size, cm
<2
0.88 (0.36-2.14)
0.782
2.00 (0.58-7.01)
0.275
0.78 (0.34-1.78)
0.558
1.71 (0.54-5.44)
0.363
2-4.9
1.70 (1.00-2.87)
0.048
2.07 (1.19-3.59)
0.010
1.73 (1.07-2.81)
0.027
2.00 (1.20-3.33)
0.008
5-9.9
2.62 (1.90-3.63)
<0.001
3.07 (2.17-4.34)
<0.001
2.42 (1.80-3.26)
<0.001
2.83 (2.05-3.91)
<0.001
≥10
2.37 (1.90-2.96)
<0.001
2.72 (2.14-3.46)
<0.001
2.28 (1.85-2.81)
<0.001
2.57 (2.05-3.22)
<0.001
Grade
Poor differentiated or undifferentiated
2.66 (1.75-4.05)
<0.001
3.10 (1.99-4.85)
<0.001
2.50 (1.67-3.75)
<0.001
3.00 (1.96-4.61)
<0.001
Well or moderately differentiated
3.35 (1.55-7.22)
0.002
2.68 (1.14-6.32)
0.024
3.38 (1.62-7.03)
0.001
2.72 (1.21-6.15)
0.016
aAge at diagnosis and year at diagnosis were included as continuous variables; all other covariates were categorical. adjusted for gender, age at diagnosis, race, marital status, site of the tumor, tumor size, chemotherapy and grade of the tumor. OS: overall survival; GSS: GIST-specific survival; GIST: gastrointestinal stromal tumor; SEER: Surveillance, Epidemiology, and End Results.
