IL-8 Is Upregulated in the Tissue-Derived EVs of Odontogenic Keratocysts

Figure 2

IL-8 expression in tissues of odontogenic lesions and IL-8 secretion is regulated by the NF-κB signaling pathway in HaCaT cells. (a, b) Representative immunohistochemical staining and score of IL-8 in odontogenic lesions including dentigerous cyst () and odontogenic keratocyst (). (c) The calcium level within the cyst fluid of odontogenic keratocyst () was calculated. (d) Thapsigargin (2 μM) significantly upregulated the intracellular calcium level within HaCaT cells in 90 seconds. (e) Thapsigargin significantly upregulated the protein level of IL-8 in HaCaT cells and partially reduced by NF-κB inhibitor (BAY 11-7082, 2 μM) in 6 h.

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