Baicalin Attenuated Aβ_1-42-Induced Apoptosis in SH-SY5Y Cells by Inhibiting the Ras-ERK Signaling Pathway

Figure 6

Baicalin inhibited Ras-ERK signaling and cyclin D1 expression in Aβ_1-42-treated SH-SY5Y cells, and this effect was reversed with a MEK activator. (a) SH-SY5Y cell extracts were prepared and analyzed by Western blotting using P-ERK, total ERK, and cyclin D1 antibodies. β-Actin antibodies were used as a reference. (b) p-ERK levels normalized to total ERK expression; cyclin D1 expression normalized to β-actin. The protein expression is presented as the . , represents , and represents .

(a)

(b)