Evaluation of Genotoxic Effect and Antigenotoxic Potential against DNA Damage of the Aqueous and Ethanolic Leaf Extracts of Annona muricata Using an In Vivo Erythrocyte Rodent Micronucleus Assay

Table 2

Frequencies of MNEs/10000 TEs in mouse peripheral blood study groups treated with different doses of A. muricata aqueous and ethanolic leaf extracts at the different sampling times.

MNEs/10000 TEs
Sampling time
	Treatments	0 h	24 h	48 h	72 h	96 h	120 h
NC; : 5	Sterile water
			NS	NS	NS	NS	NS
Aqueous extract A. muricata; : 5	187.5 mg/kg
			NS	NS	NS	NS	NS
	375 mg/kg
			NS	NS	NS	NS	NS
	750 mg/kg
			NS	NS	NS	NS	NS
EtOH extract A. muricata; : 5	187.5 mg/kg
			NS	NS	NS	NS	NS
	375 mg/kg
			NS	NS	NS	NS	NS
	750 mg/kg
			NS	NS	NS	NS	NS
PC; : 5	CP
	60 mg/kg		NS	0.002	0.013	0.009	NS

Data are expressed as . Intragroup comparisons were performed between baseline samples (0 h) against the following sampling times: 24, 48, 72, 96, and 120 h (ANOVA, Bonferroni post hoc test, ). A. muricata: Annona muricata; CP: cyclophosphamide; MNEs: micronucleated erythrocytes; : mice per group; NC: negative control; NS: not significant; PC: positive control; TEs: total erythrocytes.