Evaluation of Genotoxic Effect and Antigenotoxic Potential against DNA Damage of the Aqueous and Ethanolic Leaf Extracts of Annona muricata Using an In Vivo Erythrocyte Rodent Micronucleus Assay

Table 8

Frequencies of MNPCEs, MNEs, and PCEs from neonate peripheral blood of the pregnant rats study groups.

Groups	Treatments		MNPCEs	MNEs	PCEs
NC	Sterile water	6
			NS	NS	NS
Aqueous extract A. muricata	187.5 mg/kg	6
			NS	NS	NS
	375 mg/kg	6
			NS	NS	NS
	750 mg/kg	6
			NS	NS	NS
EtOH extract A. muricata	187.5 mg/kg	6
			NS	NS	NS
	375 mg/kg	6
			NS	NS	NS
	750 mg/kg	6
			NS	NS	NS
PC	CP	6
	60 mg/kg		0.0001	0.0001	0.0001

Data are expressed as . A. muricata aqueous and EtOH extracts were administered orally to pregnant rats. One-way ANOVA followed by the Dunnett -test for multiple post hoc pairwise comparisons versus the NC was employed to correct the significance values for intergroup analysis (). CP: cyclophosphamide; MNEs: micronucleated erythrocytes/1000 TEs; TE: total erythrocytes; MNPCEs: micronucleated polychromatic erythrocytes/1000 PCEs; : sample size (pregnant rats/6 neonates per dam); NC: negative control; NS: not significant; PC: positive control; PCEs: polychromatic erythrocytes/1000 TEs; TEs: total erythrocytes.