Integrated Analysis of Multiple Microarray Studies to Identify Core Gene-Expression Signatures Involved in Tubulointerstitial Injury in Diabetic Nephropathy

Figure 3

Identification of modules specially correlated with DN by WGCNA. (a) Sample dendrogram; (b) analysis of different soft-thresholding values from 1 to 30. (c) Evaluation of mean connectivity for each value. was selected. (d) Dendrogram of all DEGs clustered based on the dissimilarity measure (1-TOM). The original (upper bar) and merged modules (lower bar) are, respectively, shown in the two-colored bars below. (e) Network heat map plot of all the DEGs. Each row and column of the heat map belong to a single gene. The colors from red to progressive yellow represent a low to high adjacencies. (f) Module-trait relationships heat map, namely, correlation heat map of each module with clinical phenotype. (g) The relationship between the module membership and gene significance in the green (left) and blue (right) module.

(a)

(b)

(c)

(d)

(e)

(f)

(g)