Prick-by-Prick Test with Pasteurised Cow’s Milk: A Valuable Tool in Paediatric Practice

Table 3

The diagnostic performance of standard thresholds representing a positive prick-by-prick test and optimal thresholds representing a high test specificity and predicted probability.

Patient age	≤24 months		>24 months
Statistic	Value	95% CI	Value	95% CI
Area under the curve	0.94	0.88–1.00	0.86	0.75–0.97
value	<0.001		0.001
Positive PBP threshold	3 mm		3 mm
Sensitivity (%)	100.0	63.1 to 100.0	100.0	69.2 to 100.0
Specificity (%)	68.2	52.4 to 81.4	50.0	32.9 to 67.1
LR+	3.1	2.0 to 4.8	2.0	1.4 to 2.8
LR-	0.0	-	0.0	-
High specificity PBP threshold	7 mm		11 mm
Sensitivity (%)	37.5	8.5 to 75.5	10.0	0.3 to 44.5
Specificity (%)	97.7	88.0 to 99.9	94.4	81.3 to 99.3
LR+	16.5	2.0 to 139.4	1.8	0.2 to 17.9
LR-	0.6	0.4 to 1.1	1.0	0.8 to 1.2
95% predicted probability PBP threshold	11 mm		17 mm
Sensitivity (%)	0.0	0.0 to 36.9	10.0	0.3 to 44.5
Specificity (%)	97.7	88.0 to 99.9	100.0	90.3 to 100.0
LR+	0.0	-	0.0	-
LR-	1.0	1.0 to 1.1	0.9	0.7 to 1.1

PBP: prick-by-prick test; LR+: positive likelihood ratio; LR-: negative likelihood ratio.