Anticonvulsant Activity of trans-Anethole in Mice

Figure 4

Effect of TAN (200, 300, or 400 mg/kg, i.p.) administration on EEG recording after pentylenetetrazole-induced seizure test. The data were normalized by the average of the total baseline period (10 minutes) and presented as the average (line) of every 20 seconds of (a) amplitude of baseline, 3 minutes of middle section; (b) amplitude of treatment, 3 minutes of middle section; and (c) amplitude of initial 3 minutes after PTZ injection. Bar graphics represent the same data analyzed as total mean of (d) amplitude of baseline, 3 minutes of middle section; (e) amplitude of treatment, 3 minutes of middle section; and (f) amplitude of initial 3 minutes section after PTZ injection. Values represent the (–10/group). Two-way ANOVA followed by Tukey test. “” indicates a difference between the DZP and TAN 400 mg/kg groups compared to vehicle; “” indicates a difference between TAN 300 mg/kg and vehicle; and “” differentiates TAN groups compared to vehicle and DZP. , compared to the vehicle group.

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