| Reaction (PT code) | Case | ROR (95% two-sided CI) | PRR (95% two-sided CI, ) | BCPNN (IC-2SD) | EBGM (90% two-sided CI) | |
| Heart disease congenital (10019273) | 128 | 22.6 (18.88, 27.06) | 22.56 (22.38, 22.74, 2429.61) | 4.19 (4.12) | 21.02 (20.87, 21.17) | | Atrial septal defect (10003664) | 127 | 15.63 (13.07, 18.69) | 15.6 (15.42, 15.78, 1634.23) | 3.74 (3.69) | 14.86 (14.71, 15.01) | | Ventricular septal defect (10047298) | 99 | 16.12 (13.17, 19.74) | 16.1 (15.90, 16.30, 1315.07) | 3.74 (3.68) | 15.32 (15.15, 15.49) | | Patent ductus arteriosus (10034130) | 72 | 19.15 (15.09, 24.31) | 19.13 (18.89, 19.37, 1144.72) | 3.87 (3.78) | 18.02 (17.82, 18.22) | | Persistent fetal circulation (10034708) | 34 | 37.82 (26.46, 54.06) | 37.8 (37.45, 38.16, 1047.24) | 4.12 (3.95) | 33.62 (33.32, 33.92) | | Fallot’s tetralogy (10016193) | 30 | 20.42 (14.11, 29.57) | 20.41 (20.04, 20.78, 499.97) | 3.59 (3.46) | 19.16 (18.85, 19.47) | | Transposition of the great vessels (10044443) | 27 | 24.12 (16.29, 35.71) | 24.11 (23.72, 24.50, 531.58) | 3.66 (3.51) | 22.36 (22.03, 22.69) | | Pulmonary valve stenosis congenital (10037451) | 21 | 35.17 (22.37, 55.30) | 35.16 (34.70, 35.61, 592.37) | 3.72 (3.51) | 31.52 (31.14, 31.89) | | Cardiac septal defect (10064021) | 21 | 29.2 (18.65, 45.72) | 29.19 (28.74, 29.64, 494.71) | 3.62 (3.43) | 26.65 (26.27, 27.02) | | Pulmonary artery stenosis congenital (10037339) | 20 | 21.05 (13.37, 33.14) | 21.05 (20.59, 21.50, 337.90) | 3.38 (3.21) | 19.71 (19.33, 20.09) | | Coarctation of the aorta (10009807) | 19 | 14.11 (8.90, 22.35) | 14.1 (13.64, 14.56, 208.35) | 3.05 (2.91) | 13.5 (13.12, 13.89) | | Hypoplastic left heart syndrome (10021076) | 18 | 19.58 (12.15, 31.55) | 19.57 (19.09, 20.05, 280.22) | 3.26 (3.09) | 18.41 (18.01, 18.81) | | Bicuspid aortic valve (10004552) | 17 | 22.27 (13.60, 36.46) | 22.26 (21.77, 22.76, 301.45) | 3.3 (3.12) | 20.77 (20.36, 21.18) | | Newborn persistent pulmonary hypertension (10053592) | 15 | 176.83 (93.23, 335.42) | 176.79 (176.15, 177.43, 1530.31) | 3.81 (3.36) | 110.87 (110.33, 111.40) | | Haemangioma congenital (10018818) | 14 | 40.85 (23.36, 71.45) | 40.84 (40.28, 41.40, 443.43) | 3.43 (3.16) | 35.99 (35.52, 36.46) | | Congenital cardiovascular anomaly (10061054) | 14 | 8.72 (5.13, 14.84) | 8.72 (8.19, 9.25, 85.58) | 2.5 (2.37) | 8.5 (8.05, 8.94) | | Congenital heart valve disorder (10064086) | 12 | 35.36 (19.43, 64.36) | 35.36 (34.76, 35.96, 327.59) | 3.23 (2.96) | 31.68 (31.18, 32.18) | | Congenital aortic valve stenosis (10010371) | 9 | 57.66 (28.22, 117.80) | 57.65 (56.93, 58.36, 372.82) | 3.07 (2.69) | 48.38 (47.78, 48.98) | | Hypertrophic cardiomyopathy (10020871) | 9 | 7.78 (4.01, 15.08) | 7.78 (7.11, 8.44, 45.37) | 2.19 (2.04) | 7.6 (7.05, 8.16) | | Congenital coronary artery malformation (10061060) | 8 | 58.94 (27.59, 125.92) | 58.93 (58.17, 59.69, 332.75) | 2.95 (2.54) | 49.27 (48.64, 49.91) | | Trisomy 21 (10044688) | 8 | 5.12 (2.55, 10.31) | 5.12 (4.43, 5.82, 22.19) | 1.8 (1.67) | 5.05 (4.47, 5.64) | | Pulmonary artery atresia (10037337) | 8 | 47.15 (22.35, 99.46) | 47.14 (46.40, 47.89, 272.85) | 2.91 (2.53) | 40.78 (40.15, 41.40) | | Double outlet right ventricle (10013611) | 7 | 18.42 (8.58, 39.53) | 18.42 (17.65, 19.18, 92.68) | 2.51 (2.24) | 17.39 (16.75, 18.03) | | Shone complex (10066802) | 6 | 104 (41.00, 263.80) | 103.99 (103.06, 104.92, 379.20) | 2.69 (2.11) | 77.13 (76.35, 77.90) | | Aorta hypoplasia (10049209) | 5 | 16.01 (6.51, 39.39) | 16.01 (15.11, 16.91, 53.23) | 2.17 (1.88) | 15.24 (14.49, 15.99) | | Congenital mitral valve stenosis (10010548) | 5 | 73.67 (27.65, 196.29) | 73.66 (72.68, 74.64, 231.34) | 2.46 (1.90) | 59.13 (58.31, 59.95) | | Multiple cardiac defects (10028178) | 5 | 22.32 (8.99, 55.41) | 22.32 (21.41, 23.23, 75.82) | 2.27 (1.93) | 20.82 (20.06, 21.58) | | Anomalous pulmonary venous connection (10058079) | 4 | 12.41 (4.56, 33.74) | 12.41 (11.41, 13.41, 30.02) | 1.9 (1.61) | 11.95 (11.11, 12.78) | | Atrioventricular septal defect (10063836) | 4 | 7.96 (2.95, 21.50) | 7.96 (6.97, 8.96, 17.40) | 1.72 (1.49) | 7.78 (6.95, 8.61) | | Congenital aortic stenosis (10010369) | 4 | 13.87 (5.09, 37.80) | 13.87 (12.86, 14.87, 34.11) | 1.94 (1.63) | 13.29 (12.45, 14.13) | | Corrected transposition of great vessels (10011120) | 4 | 589.33 (107.94, 3217.69) | 589.29 (587.60, 590.99, 598.66) | 2.29 (1.20) | 197.1 (195.68, 198.52) | | Ventricular hypoplasia (10047296) | 3 | 10.16 (3.21, 32.12) | 10.16 (9.01, 11.31, 15.89) | 1.61 (1.31) | 9.85 (8.89, 10.82) | | Univentricular heart (10045545) | 3 | 18.81 (5.85, 60.43) | 18.81 (17.64, 19.97, 32.23) | 1.77 (1.37) | 17.74 (16.76, 18.72) | | Truncus arteriosus persistent (10044703) | 3 | 23.89 (7.37, 77.49) | 23.89 (22.71, 25.07, 41.47) | 1.81 (1.36) | 22.17 (21.19, 23.16) | | Congenital pulmonary artery anomaly (10061074) | 3 | 19.22 (5.98, 61.79) | 19.22 (18.05, 20.38, 32.99) | 1.77 (1.37) | 18.1 (17.12, 19.08) | | Congenital tricuspid valve stenosis (10010656) | 3 | 73.67 (20.79, 261.06) | 73.66 (72.40, 74.93, 118.64) | 1.92 (1.20) | 59.13 (58.07, 60.19) | | Congenital pulmonary valve atresia (10052644) | 3 | 8.26 (2.62, 26.02) | 8.26 (7.11, 9.41, 12.21) | 1.54 (1.27) | 8.06 (7.10, 9.02) | | Dextrocardia (10012592) | 3 | 15.24 (4.78, 48.64) | 15.24 (14.08, 16.40, 25.58) | 1.73 (1.36) | 14.54 (13.57, 15.51) | | Congenital pulmonary valve disorder (10061075) | 2 | 15.93 (3.84, 66.09) | 15.93 (14.50, 17.35, 14.24) | 1.4 (0.95) | 15.16 (13.97, 16.35) | | Trisomy 18 (10053884) | 2 | 5.12 (1.27, 20.74) | 5.12 (3.73, 6.52, 3.09) | 1.1 (0.83) | 5.05 (3.88, 6.22) | | Hypoplastic right heart syndrome (10064962) | 2 | 8.93 (2.19, 36.46) | 8.93 (7.52, 10.34, 7.04) | 1.28 (0.93) | 8.7 (7.52, 9.87) | | Noonan syndrome (10029748) | 2 | 39.29 (8.98, 171.81) | 39.29 (37.81, 40.76, 36.31) | 1.5 (0.82) | 34.78 (33.55, 36.02) | | Congenital arterial malformation (10062325) | 2 | 11.56 (2.81, 47.47) | 11.55 (10.14, 12.97, 9.76) | 1.34 (0.95) | 11.16 (9.97, 12.34) | | Vascular malformation (10074979) | 2 | 8.54 (2.09, 34.84) | 8.54 (7.13, 9.95, 6.63) | 1.27 (0.93) | 8.33 (7.15, 9.50) | | Right ventricle outflow tract obstruction (10064195) | 2 | 14.03 (3.40, 57.97) | 14.03 (12.61, 15.45, 12.31) | 1.38 (0.95) | 13.44 (12.25, 14.63) | | Congenital aortic anomaly (10061052) | 2 | 8.67 (2.12, 35.36) | 8.67 (7.26, 10.07, 6.76) | 1.27 (0.93) | 8.45 (7.27, 9.62) | | Congenital mitral valve incompetence (10010547) | 2 | 13.7 (3.32, 56.58) | 13.7 (12.29, 15.12, 11.98) | 1.38 (0.95) | 13.14 (11.95, 14.33) | | Interruption of aortic arch (10022599) | 2 | 22.67 (5.38, 95.50) | 22.67 (21.23, 24.10, 20.92) | 1.45 (0.91) | 21.12 (19.91, 22.32) | | Cor triatriatum (10010972) | 1 | 49.11 (5.91, 407.93) | 49.11 (46.99, 51.22, 9.62) | 0.96 (-0.06) | 42.24 (40.46, 44.01) | | Digeorge’s syndrome (10012979) | 1 | 7.96 (1.09, 58.04) | 7.96 (5.98, 9.95, 1.08) | 0.82 (0.36) | 7.78 (6.12, 9.44) | | Heart block congenital (10019263) | 1 | 10.91 (1.48, 80.31) | 10.91 (8.92, 12.91, 1.74) | 0.87 (0.33) | 10.56 (8.89, 12.23) | | Trisomy 13 (10044686) | 1 | 5.56 (0.77, 40.20) | 5.56 (3.58, 7.54, 0.55) | 0.75 (0.36) | 5.48 (3.82, 7.13) | | Congenital aortic dilatation (10058150) | 1 | 32.74 (4.15, 258.43) | 32.74 (30.67, 34.80, 6.45) | 0.95 (0.08) | 29.56 (27.84, 31.29) | | Persistent left superior vena cava (10064193) | 1 | 8.42 (1.15, 61.45) | 8.42 (6.43, 10.41, 1.18) | 0.83 (0.36) | 8.21 (6.55, 9.88) | | Aorticopulmonary septal defect (10063732) | 1 | 32.74 (4.15, 258.43) | 32.74 (30.67, 34.80, 6.45) | 0.95 (0.08) | 29.56 (27.84, 31.29) | | Malformation venous (10025532) | 1 | 10.16 (1.38, 74.59) | 10.16 (8.17, 12.15, 1.57) | 0.86 (0.34) | 9.85 (8.19, 11.52) | | Ebstein’s anomaly (10014075) | 1 | 5.17 (0.72, 37.33) | 5.17 (3.19, 7.15, 0.47) | 0.74 (0.36) | 5.1 (3.44, 6.75) | | Fallot’s pentalogy (10059205) | 1 | 147.33 (13.36, 1624.84) | 147.32 (144.92, 149.72, 23.73) | 0.98 (-0.46) | 98.55 (96.54, 100.56) | | Ductus arteriosus stenosis fetal (10013808) | 1 | 1.94 (0.27, 13.85) | 1.94 (-0.03, 3.90, 0.00) | 0.4 (0.16) | 1.93 (0.29, 3.58) | | Ductus arteriosus premature closure (10049996) | 1 | 1.89 (0.26, 13.49) | 1.89 (-0.08, 3.86, 0.00) | 0.38 (0.15) | 1.88 (0.24, 3.53) | | Vacterl syndrome (10066022) | 1 | 5.36 (0.74, 38.71) | 5.36 (3.38, 7.33, 0.51) | 0.75 (0.36) | 5.28 (3.62, 6.93) | | Congenital aortic atresia (10010368) | 1 | 24.55 (3.19, 188.85) | 24.55 (22.51, 26.59, 4.75) | 0.93 (0.16) | 22.74 (21.04, 24.45) | | Ectopia cordis (10014144) | 1 | 58.93 (6.88, 504.44) | 58.93 (56.78, 61.08, 11.38) | 0.97 (-0.12) | 49.27 (47.48, 51.07) | | Cardiac malposition (10007585) | 1 | 36.83 (4.61, 294.50) | 36.83 (34.75, 38.91, 7.27) | 0.95 (0.04) | 32.85 (31.11, 34.59) | | Mitral valve atresia (10066800) | 1 | 15.51 (2.08, 115.85) | 15.51 (13.50, 17.52, 2.77) | 0.9 (0.27) | 14.78 (13.10, 16.47) | | Congenital tricuspid valve atresia (10049767) | 1 | 5.17 (0.72, 37.33) | 5.17 (3.19, 7.15, 0.47) | 0.74 (0.36) | 5.1 (3.44, 6.75) | | Charge syndrome (10064063) | 1 | 32.74 (4.15, 258.43) | 32.74 (30.67, 34.80, 6.45) | 0.95 (0.08) | 29.56 (27.84, 31.29) | | Right aortic arch (10067407) | 1 | 4.68 (0.65, 33.72) | 4.68 (2.70, 6.65, 0.37) | 0.71 (0.36) | 4.62 (2.97, 6.27) | | Congenital aortic valve incompetence (10010370) | 1 | 4.53 (0.63, 32.67) | 4.53 (2.56, 6.51, 0.34) | 0.71 (0.35) | 4.48 (2.83, 6.13) | |
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