[Retracted] CD73 (NT5E) Promotes the Proliferation and Metastasis of Lung Adenocarcinoma through the EGFR/AKT/mTOR Pathway

Figure 5

CD73 binds to EGFR to activate the AKT/mTOR signaling pathway in vitro. (a) Immunoprecipitation was used to determine the interaction between CD73 and EGFR in the A549 cell line. (b) Representative western blots of p-EGFR, EGFR, p-AKT, AKT, p-mTOR, and mTOR in the A549 cells following transfection with siRNA or overexpression plasmid or treated with APCP. The ratio of (c) p-EGFR/EGFR, (d) p-AKT/AKT, and (e) p-mTOR/mTOR in the A549 cells following transfection with siRNA, overexpression plasmid, or treatment with APCP. Each experiment was performed three times. The data are presented as the . ^& between two groups. LUAD: lung adenocarcinoma; si: small interfering; p: phosphorylated.

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