A Novel-Defined Necroptosis-Related miRNA Signature for Forecasting the Prognosis of Low-Grade Glioma

Table 1

Univariate and multivariate Cox regression of 5 significant differentially expressed miRNAs and clinical factors.

Characteristics	Total ()	Univariate analysis		Multivariate analysis
		Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	value
hsa-miR-141-3p	528	1.665 (1.326-2.091)	<0.001	1.281 (0.949-1.730)	0.106
hsa-miR-148a-3p	528	1.394 (1.268-1.532)	<0.001	1.225 (1.022-1.467)	0.028
hsa-miR-200a-5p	528	1.835 (1.506-2.236)	<0.001	1.064 (0.769-1.473)	0.706
hsa-miR-223-3p	528	1.199 (1.054-1.365)	0.006	1.006 (0.843-1.201)	0.946
hsa-miR-500a-3p	528	1.186 (0.972-1.448)	0.093	0.749 (0.579-0.968)	0.027
WHO grade	466
G2	220	Reference
G3	246	3.032 (2.020-4.551)	<0.001	1.929 (1.182-3.148)	0.009
Age	528
≤40	264	Reference
>40	264	2.888 (2.004-4.162)	<0.001	2.960 (1.802-4.861)	<0.001
Gender	528
Female	240	Reference
Male	288	1.121 (0.797-1.577)	0.512
IDH status	525
WT	97	Reference
Mut	428	0.182 (0.128-0.260)	<0.001	0.463 (0.225-0.954)	0.037
1p/19q codeletion	528
Codel	171	Reference
Noncodel	357	2.488 (1.586-3.904)	<0.001	0.944 (0.484-1.840)	0.865
Primary therapy outcome	458
PD	110	Reference
SD	148	0.428 (0.283-0.648)	<0.001	0.361 (0.213-0.611)	<0.001
PR	63	0.172 (0.075-0.397)	<0.001	0.171 (0.060-0.484)	<0.001
CR	137	0.119 (0.055-0.260)	<0.001	0.151 (0.067-0.341)	<0.001
Race	517
Asian	8	Reference
Black or African American	22	4849148.928 (0.000-Inf)	0.993
White	487	3285138.716 (0.000-Inf)	0.993
Histological type	528
Astrocytoma	196	Reference
Oligoastrocytoma	133	0.652 (0.413-1.029)	0.066	1.524 (0.860-2.699)	0.149
Oligodendroglioma	199	0.582 (0.396-0.855)	0.006	0.643 (0.351-1.176)	0.152
Laterality	523
Left	257	Reference
Midline	7	1.033 (0.312-3.425)	0.958
Right	259	0.780 (0.549-1.108)	0.165

Annotation: WT: wild type; Mut: mutation; PD: progress disease; SD: stable disease; PR: partial response; CR: complete response.