Chalcone Derivatives as Potential Inhibitors of P-Glycoprotein and NorA: An In Silico and In Vitro Study

Table 2

MIC values (μg/ml) of ciprofloxacin (Ci) and synthesized chalcones when used alone and in combination with each of the chalcones on different strains of S. aureus.

S. aureus strain	MIC (μg/ml)
	Ci	F29	F88	F90	F91	Ci+F29	Ci+F88	Ci+F90	Ci+F91
SA-1199^†	<0.125	512	512	512	512	<0.125	<0.125	<0.125	<0.125
SA-1199B^†	4	>512	>512	>512	>512	4	2	2	4
I16.1421^‡	0.5	512	256	512	512	0.125	0.125	0.125	0.5
I16.1505^‡	32	512	512	512	512	32	16	32	32
I16.1562^‡	32	>512	256	>512	>512	32	16	32	32
I16.1635^‡	32	256	>512	256	>512	32	16	16	16
I16.1672^‡	32	>512	512	512	>512	16	16	16	16

Concentrations of the chalcones: ^†50 μg/ml and ^‡20 μg/ml.