Gene Signatures and Associated Transcription Factors of Allergic Rhinitis: KLF4 Expression Is Associated with Immune Response

Figure 2

Immune response-related genes are enriched in AR. (a) A Venn diagram shows the overlapping genes among the immune response- and response to cytokine-related genes and DEGs between AR and HC. (b) Point plot showing the enrichment score of immune response (top). Heatmap showing the expression pattern of DEGs-dependent immune response-related genes (, bottom). A barplot showing the fold change of DEGs-dependent immune response-related genes (right). (c) Boxplots show the expression levels of POSTN ( value, Student -test). (d) Heatmap shows the enrichment score of immune- and cytokine-related signatures. (e) Boxplots show the expression levels of IL1RL1, CD274, and CD44 ( value, one-way ANOVA test). (f) Heatmap shows the enrichment score of immune cell-related signatures. (g) Boxplots show the expression levels of IL1B ( value, one-way ANOVA test).

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