Molecular Investigation of the Antitumor Effects of Monoamine Oxidase Inhibitors in Breast Cancer Cells

Figure 3

Dot plot for annexin V-FITC/PI staining expressing the apoptotic effect of double IC₅₀ of MAO-AIs (J14, J16, J19, and J25) treatment for 48-hour treatment against (a) MDA-MB-231 and (b) T-47D cells and its quantitative comparison of each cell phase, where Q3 showed viable cells, Q1 necrotic cells, Q2 late apoptotic, and Q4 early apoptotic. Percentages of healthy, apoptotic, and necrotic cells expressed as mean, SD did not exceed 5%. P-value <0.05 indicates statistical significance in comparison to untreated control, while asterisk: ^ns (not significant); ; ; ; (according to GraphPad Prism 9).

(a)

(b)