Glutathione Upregulates the Expression of K_ATP Channels and Vasorelaxation Responses and Inhibits mPTP Opening and Oxidative Stress in the Heart Mitochondria of Old Rats

Figure 2

Vasodilatory effects of openers of K_ATP channels of flocalin (a) and pinacidil (b) in experiments on isolated aortic rings of adult (6 months) and old (24 months) male Wistar rats, as well as old male glutathione-treated animals. GSH: glutathione. GBC: glibenclamide. Data are represented as . For adult rats, ; for old rats, ; for old glutathione-treated rats, . compared to old rats. ^# compared to old glutathione-treated rats. The figure shows that the relaxation of vascular rings in response to the activation of K_ATP channels by flocalin did not differ in adult and old rats (a). At the same time, the administration of glutathione to old rats significantly enhances the vasodilatory reactions of the K_ATP channel openers floсalin (a) and pinacidil (b). The vasodilator effects of floсalin and pinacidil were prevented by the K_ATP channel inhibitor glibenclamide.

(a)

(b)