Antiseizure Effects of Peganum harmala L. and Lavandula angustifolia

Table 4

Effect of naloxone on the antiseizure activity of Peganum harmala L. in pentylenetetrazol- (PTZ-) induced seizures in mice^a.

Treatment	Dose	Latency to seizure onset (sec)	Tonic-clonic onset (sec)	Seizure duration (sec)	Death time (sec)	Mortality protection rate (%)
Normal saline	10 ml/kg					0
Naloxone	5 mg/kg					20
P. harmala	10 mg/kg				—	90
P. harmala+naloxone	10 mg/kg, 5 mg/kg				—	90
value	—	0.000^#	0.000^#	0.000^#	0.102^##	—
Test statistic	—	26.572^#	20.623^#	25.344^#	25.000^##	—

^# values and test statistics (H) refer to the Kruskal-Wallis test. ^## values and test statistics (U) refer to the Mann–Whitney U test. and compared with the normal saline group; refer to the post hoc tests (Dunn’s test). ^aThe results of post hoc analyses that compare the effects of Peganum harmala and Peganum harmala+naloxone are indicated in Figure 2.