An Enriched Environment Promotes Motor Function through Neuroprotection after Cerebral Ischemia

Figure 5

Effects of EE on Bcl-2 and Bax (a–c) and SYN and GAP-43 (d–f) expressions in the peri-infarct cortex. SYN integral optical density (IOD). (a) Representative immunofluorescence images of Bcl-2 and Bax (red) in the EE, SH, and sham groups. Scale . (b) Bar graph showing the immunofluorescence quantification of the expression of Bcl-2/Bax among different groups. vs. SH group. ^# vs. sham group. (c) Representative immunofluorescence images of SYN (red) in the EE, SH, and sham groups. Scale . (d) Bar graph showing the immunofluorescence quantification of the expression of SYN in the different groups. vs. SH group. ^# vs. sham group. (e) Representative immunofluorescence images of GAP-43 (red) in the EE, SH, and sham groups. Scale . (f) Bar graph showing the immunofluorescence quantification of the expression of GAP-43 in the different groups. vs. SH group. ^# vs. sham group. Data are expressed as the (; one-way analysis of variance followed by Fisher’s least significant difference post hoc test). Bax: Bcl-2-associated X protein; Bcl-2: B-cell lymphoma-2; EE: enriched environment; GAP-43: growth-associated protein 43; SH: standard housing; SYN: synaptophysin.

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