Role of Kir4.1 Channels in Aminoglycoside-Induced Ototoxicity of Hair Cells

Figure 6

Changes in Kir4.1 expression in control and ototoxic mice. (a–d) Kir4.1 expression in control mice. (a) Expression of Kir4.1 in stria vascularis (StV) and outer hair cells (OHC) of control mice. (b) Pattern of staining with 4,6-diamidino-2-phenylindole (DAPI). (c) Merged image. (d) High expression of Kir4.1 in OHC. (e–h) Kir4.1 expression in ototoxic mice. (e) Expression of Kir4.1 in StV and OHC of ototoxic mice. (f) Pattern of DAPI staining. (g) Merged image. (h) Organ of Corti displayed decreased intensity expression of Kir4.1 in OHC.