Role of Kir4.1 Channels in Aminoglycoside-Induced Ototoxicity of Hair Cells

Figure 7

Changes in expression of Kir4.1 ex vivo. Kir4.1 expression in outer hair cells and inner hair cells (OHC) in cochlear explants of control and ototoxic mice. (a–c) Explant of the control mouse. (a) Kir4.1 is strongly expressed in OHC. (b) Upon DAPI staining, cell loss was observed. (d–f) Explant of ototoxic mouse. (d) The expression of Kir4.1 in OHC was decreased compared to the control. (e) Upon DAPI staining, cell loss was observed in OHC.