Research Article
Formulation and In Vitro Evaluation of Furosemide Floating Matrix Tablets Using Boswellia papyrifera Resin as Matrix Forming Polymer
Table 5
Effects of formulation factors on response variables FLT, TFT, and CR in 12 hrs.
| | Factors | Response variables | | FLT (sec) | TFT (hrs) | CR in 12 hrs (%) |
| | Olibanum resin (10% NaHCO3) | | 10% (B1) | | 2 | 99.50 | | 40% (B2) | | >12 | 98.25 | | HPMC K4M (10% NaHCO3) | | 10% (B3) | | Nonintact | 102.00 | | 40% (B4) | | >12 | 97.25 | | Olibanum resin/HPMC K4M ratio (10%) (10%NaHCO3) | | 1 : 1 (B5) | | Nonintact | 99.62 | | 1 : 3 (B6) | | Nonintact | 102.32 | | 3 : 1 (B7) | | 1.8 | 101.55 | | Olibanum resin/HPMC K4M ratio (40%) (10%NaHCO3) | | 1 : 1 (B8) | | >12 | 80.62 | | 1 : 3 (B9) | | >12 | 68.60 | | 3 : 1 (B10) | | >12 | 80.32 | | NaHCO3 (40% olibanum resin) | | 10% (B2) | | >12 | 98.25 | | 20% (B11) | | 3.8 | 100.57 | | NaHCO3 (40% HPMC K4M) | | 10% (B4) | | >12 | 97.25 | | 20% (B12) | | >12 | 99.00 |
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CR = cumulative release; FLT = floating lag time; TFT = total floating time.
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