Research Article

Bioassay-Guided Isolation of Antiplasmodial Compounds from Hypericum lanceolatum Lam. (Hypericaceae) and Their Cytotoxicity and Molecular Docking

Table 2

Antiplasmodial and cytotoxicity activities of extracts and isolated compounds.

CompoundsAntiplasmodial (Pf 3D7)Cytotoxicity (P388)SI
Parasite survivalIC50 (μg/mL)IC50 (μg/mL)

F162.3%
F232.6%
F392.4%
F4108.3%
10.5
20.4
32.4
40.2
Chloroquine
Cisplatin

% parasite survival at 10 μg/mL. F1: hexane-soluble fraction; F2: CH2Cl2-soluble fraction; F3: EtOAC-soluble fraction; F4: n-butanol-soluble fraction; SI: selectivity index.