Efficiency of Hesperidin against Liver Fibrosis Induced by Bile Duct Ligation in Rats

Figure 1

Effects of hesperidin on the histopathological changes of the liver in BDL-afflicted rats. Representative photomicrographs of liver sections processed for H and E staining (10; scale bar 5 mm). Sham ×400 (a); BDL-control ×100 (b); BDL+VitC ×100 (c); BDL+Hesp100 ×100 (d); BDL+Hesp100 ×400 (e); and BDL+Hesp200 ×100 (f). (a) represents the normal liver histopathology. (e) is a section of (d) at ×400 magnification. In (b)–(e), bile duct hyperplasia is evident. All these lesions markedly decreased in rats treated with 200 mg/kg hesperidin.