Insampaedok-San Extract Exerts an Immune-Enhancing Effect through NF-κB p65 Pathway Activation

Table 4

Chemical information and quantitative analysis of authentic key components in ISE.

Peak no.	Compound name	Molecular formula	Degree in network	Correlating targets	Rt (min)	Adduct	Calculated molecular ions	Measured molecular ions (m/z)	Error (ppm)	Score	Origin
1	Ferulic acid	C10H10O4	3	TNF; IL6; STAT3	4.662	(M+H)^+ [-H2O]	194.0573	177.0541	3.31	95.76	O. koreanum, A. continentalis, P. ginseng, C. aurantium, C. officinale
2	Isoglabrolide	C30H44O4	3	IL1B; MAPK14; STAT3	8.247	(M+H)^+	468.324	469.3317	-0.83	99.34	G. uralensis
3	Neocnidilide	C12H18O2	3	IL1B; MAPK14; STAT3	8.748	(M+H)^+	194.1307	195.1372	4.84	91.15	C. officinale
4	Glabric acid	C30H46O5	3	TNF; IL6; MAPK3	8.875	(M+H)^+	486.334	487.3424	1.22	99.05	G. uralensis
5	Liquiritic acid	C30H46O4	3	TNF; IL6; MAPK3	9.404	(M+H)^+ [-H2O]	470.3396	453.3367	-1.12	96.15	G. uralensis
6	Scopoletin	C10H8O4	4	TNF; IL1B; MAPK14; STAT3	10.887	(M+H)^+ [-H2O]	192.0414	175.0381	4.49	92.45	O. koreanum, A. continentalis, A. decursiva, C. aurantium, C. officinale
7	Erybacin B	C19H18O5	3	TNF; STAT3; MAPK14	15.375	(M+H)^+	326.1154	327.1236	-2.09	96.77	G. uralensis