Antibacterial and Immunoregulatory Effects of Metformin against Helicobacter pylori Infection in Rat Model

Figure 1

Metformin reduces the effective dose of AMX against H. pylori. (a) Growth curve of metformin at different concentrations (0.1, 0.2, 0.5, and 1 M) at regular intervals (4, 8, 12, 16, 20, and 24 h). (b) In vivo antibacterial activity of metformin alone and in combination with AMX. (c) The distribution of H. pylori on the biopsy section, Giemsa’s staining. (d) Metformin significantly reduced body weight at two concentrations (100 and 200 mg/kg) for two weeks compared with the control group (which received normal saline). The values are presented as the mean and the standard error of the mean (SEM). , , , and .

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