Antibacterial and Immunoregulatory Effects of Metformin against Helicobacter pylori Infection in Rat Model

Figure 3

Compared with AMX administration, metformin administration shifts the Treg/Th17 ratio toward a population with a higher number of Treg cells. (a) Flow cytometry characterization shows positive expression of RORγt⁺ (left panel) and coexpression of CD25⁺ and Foxp3⁺ (right panel) among CD4⁺ T cells for Th17 and Treg cells, respectively. (b) Comparison of the percentage of Th17 cells in the different treatment groups. (c) Comparison of the percentage of Treg cells in the different treatment groups. (d) Treg/Th17 ratio in the different treatment groups. Values are shown as mean and SD. .

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