Antibacterial and Immunoregulatory Effects of Metformin against Helicobacter pylori Infection in Rat Model

Figure 6

Histological evaluation, (a) H&E and (b) IHC staining of biopsies, the NS groups showed severe chronic superficial gastritis with chronic inflammatory cells including polymorphonuclear and mononuclear cells (red circle and red arrow), the Met-1 group showed typical mild colonization of H. pylori in the antrum pits with reduced infiltration of immune cells (green circle and black arrow), and the Met-1/AMX-1 group showed bacterial clearance (green arrow) and very low infiltration of immune cells.