Upregulation of miR-20a-5p as the Potential MicroRNA Marker in Red Blood Cell Storage Lesion

Table 2

Twenty-two target genes of miR-20a-5p in PRBC storage lesion.

Gene	Chromosomal location	Gene groups	Functions
ATAD2	8q24.13	AAA ATPases	DNA replication, protein degradation, membrane fusion, microtubule severing, peroxisome biogenesis, signal transduction, and regulation of gene expression
DDX5	17q23.3	DEAD-box helicases	RNA metabolism
E2F1	20q11.22	E2F transcription factors	Cell cycle regulation and synthesis of DNA in mammalian cells
EPHA5	4q13.1-q13.2	EPH receptors	Long-term potentiation, angiogenesis, and stem cell differentiation and cancer
EPHA7	6q16.1	EPH receptors	Long-term potentiation, angiogenesis, and stem cell differentiation and cancer
FEM1B	15q23	Ankyrin repeat domain-containing	Protein-protein interaction domains
FNBP1L	1p22.1	F-BAR domain containing	Dimerization and membrane phospholipid binding
FOXL2	3q22.3	Forkhead boxes	Cell growth, proliferation, differentiation, and longevity
HIF1A	14q23.2	Basic helix-loop-helix proteins	DNA binding
KATNAL1	13q12.3	AAA ATPases	DNA replication, protein degradation, membrane fusion, microtubule severing, peroxisome biogenesis, signal transduction, and regulation of gene expression
KPNA3	13q14.2	Armadillo repeat-containing	Linking cadherin cell adhesion proteins to the cytoskeleton and transducing WNT signals during embryonic development
MCC	5q22.2	EF-hand domain containing	Binds calcium ions
MID1	Xp22	Ring finger proteins	Ubiquitination pathway
MXI1	10q25.2	Basic helix-loop-helix proteins	DNA binding
NBEA	13q13.3	A-kinase anchoring proteins	Binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell
NPAS3	14q13.1	Basic helix-loop-helix proteins	DNA binding
PTPN21	14q31.3	FERM domain containing	Plasma membrane and the cytoskeleton
RNF6	13q12.13	Ring finger proteins	Ubiquitination pathway
SAR1B	5q31.1	ARF GTPase family	Vesicle biogenesis in intracellular traffic
SCN2B	11q23.3	V-set domain containing	Myelin membrane adhesion molecules, junction adhesion molecules (JAM), tyrosine-protein kinase receptors, and programmed cell death protein 1 (PD1)
TANC1	2q24.2	Ankyrin repeat domain-containing	Protein-protein interaction domains
TIAM1	21q22.11	PDZ domain-containing	Anchoring of cell surface receptors (such as CFTR and FZD7) to the actin cytoskeleton via mediators like NHERF and ezrin
		Pleckstrin homology domain containing	Recruiting proteins to different membranes and cellular compartments or enabling them to interact with other components of the signal transduction pathways