Upregulation of miR-20a-5p as the Potential MicroRNA Marker in Red Blood Cell Storage Lesion

Table 3

Packed red blood cell (PRBCs) storage lesion.

RBC storage lesion	Structural; (i) Lose membrane phospholipids; (ii) Shape change; (iii) Clumping	Biochemical; (i) ↓ ATP; (ii) ↓ 2,3-DPG; (iii) ↓ NO.	Immunological (soluble bioactive substances); (i) Microparticles; (ii) Cell-free DNA; (iii) Bioactive lipids
Complications	Cellular necrosis	(i) Impaired vasodilation; (ii) O2 delivery	(i) Inflammation; (ii) Infection; (iii) Hypercoagulability; (iv) Endothelial injury
Outcomes	(i) ↓ Microvascular perfusion and O2; (ii) ↑ MOF and death