Investigation of the Active Compounds and Important Pathways of Huaiqihuang Granule for the Treatment of Immune Thrombocytopenia Using Network Pharmacology and Molecular Docking

Table 2

The key targets of HQHG for ITP treatment and the topological parameters.

Gene name	Target name	UniProt ID	Target class	BetweennessCentrality	ClosenessCentrality	Degree	TopologicalCoefficient
ALB	Serum albumin	P02768	Secreted protein	0.116336	0.69924812	111	0.238997
TNF	TNF-alpha	P01375	Secreted protein	0.087174	0.69662921	110	0.248704
GAPDH	Glyceraldehyde-3-phosphate dehydrogenase liver	P04406	Oxidoreductase	0.103707	0.69144981	107	0.240194
SRC	Tyrosine-protein kinase SRC	P12931	Kinase	0.042761	0.62207358	83	0.237859
EGFR	Epidermal growth factor receptor erbB1	P00533	Kinase	0.049119	0.62207358	82	0.254689
STAT3	Signal transducer and activator of transcription 3	P40763	Transcription factor	0.030602	0.61589404	81	0.232068
CASP3	Caspase-3	P42574	Protease	0.027922	0.61386139	78	0.220249
MMP9	Matrix metalloproteinase 9	P14780	Protease	0.015639	0.57943925	68	0.249442
ESR1	Estrogen receptor alpha	P03372	Nuclear receptor	0.025108	0.58490566	65	0.226744
PTGS2	Cyclooxygenase-2	P35354	Oxidoreductase	0.019666	0.5830721	65	0.219843
PPARG	Peroxisome proliferator-activated receptor gamma	P37231	Nuclear receptor	0.024164	0.5830721	63	0.180814
TLR4	Toll-like receptor 4 (by homology)	O00206	Toll-like and Il-1 receptors	0.011561	0.56534954	62	0.209176
CCND1	Carbonyl reductase [NADPH] 1	P16152	Enzyme	0.017068	0.57230769	61	0.231736
IL2	Interleukin-2	P60568	Secreted protein	0.012506	0.56363636	56	0.218021
ERBB2	Receptor protein-tyrosine kinase erbB-2	P04626	Kinase	0.009878	0.56193353	56	0.174705
ICAM1	Isoleucyl-tRNA synthetase	P41252	Enzyme	0.006515	0.55855856	55	0.206215
MAPK1	MAP kinase ERK2	P28482	Kinase	0.008731	0.55522388	51	0.2468
PIK3CA	PI3-kinase p110-alpha subunit	P42336	Enzyme	0.008804	0.54069767	49	0.215699
ITGB1	Intercellular adhesion molecule (ICAM-1), integrin alpha-L/beta-2	P20701 P05362 P05107	Membrane receptor	0.006189	0.55192878	49	0.180651
ACE	Angiotensin-converting enzyme	P12821	Protease	0.015263	0.54867257	48	0.232635