Using Appetitive Motivation to Train Mice for Spatial Learning in the Barnes Maze

Figure 2

First hole distance from the target hole (a–c) and distance travelled (d–f) in the food-motivated Barnes maze task. values are shown. Performance of NMRI (Exp1) (a, d) and C57BL/6 (Exp2) mice (b, e) in the slow protocol. (c, f) Performance of NMRI mice in the massive protocol (Exp3). Black lines and symbols show the pooled data of the two subgroups (“out of hand” and “out of box”). Gray lines and symbols show the data of the two subgroups. S.E.M. bars are omitted from these curves for the sake of clarity. , , and vs. 1st trial; ^++,+++ and vs. previous trial. The arrow indicates that the trial and the following trials significantly differ from trial 1.

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