Nomogram to Predict Long-Term Overall Survival and Cancer-Specific Survival of Radiotherapy Patients with Nasopharyngeal Carcinoma

Table 2

Univariate Cox regression analysis of overall survival and cancer-specific survival in nasopharyngeal carcinoma in the training cohort.

Variables	Overall survival			Cancer-specific survival
	HR	95% CI		HR	95% CI
Total
Age group (years)
<50	Reference			Reference
50-64	1.854	1.628-2.112	<0.001	1.639	1.420-1.891	<0.001
≥65	3.419	2.989-3.912	<0.001	2.490	2.136-2.903	<0.001
Sex
Male	Reference			Reference
Female	0.884	0.791-0.9883	0.03	0.882	0.775-1.002	0.054
Race
Black	Reference			Reference
White	1.031	0.886-1.201	0.693	0.924	0.777-1.099	0.372
Asian/Pacific islander	0.601	0.509-0.707	<0.001	0.631	0.525-0.759	<0.001
Indian/Alaska native	1.455	1.017-2.083	0.040	1.412	0.939-2.122	0.097
Marital status
Single	Reference			Reference
Married	0.971	0.855-1.104	0.655	0.925	0.801-1.069	0.292
Divorced	1.624	1.357-1.945	<0.001	1.493	1.213-1.837	<0.001
Windowed/separated	2.486	2.058-3.004	<0.001	2.113	1.693-2.636	<0.001
Histology
KSCC	Reference			Reference
DNKC	0.599	0.523-0.686	<0.001	0.619	1.616-0.722	<0.001
UNKC	0.446	0.379-0.522	<0.001	0.429	2.328-0.518	<0.001
Others	0.724	0.639-0.820	<0.001	0.707	1.414-0.817	<0.001
Grade
Well	Reference			Reference
Moderate	1.106	0.774-1.580	0.581	1.135	0.747-1.726	0.553
Poor	0.744	0.531-1.043	0.086	0.795	0.535-1.182	0.258
Undifferentiated	0.463	0.329-0.653	<0.001	0.478	0.319-0.715	<0.001
Unknown	0.667	0.475-0.936	0.019	0.699	0.469-1.042	0.079
Tumor size (cm)
<3	Reference			Reference
3-5	1.348	1.147-1.585	<0.001	1.377	1.137-1.667	<0.001
>5	2.089	1.738-2.510	<0.001	2.387	1.933-2.946	<0.001
Unknown	1.521	1.308-1.768	<0.001	1.634	1.368-1.953	<0.001
AJCC stage
I	Reference			Reference
II	1.038	0.827-1.303	0.748	1.259	0.924-1.716	0.144
III	1.289	1.036-1.603	0.023	1.857	1.383-2.494	<0.001
IV	2.268	1.838-2.799	<0.001	3.551	2.668-4.726	<0.001
T stage
T1	Reference			Reference
T2	1.117	0.968-1.288	0.129	1.217	1.028-1.441	0.023
T3	1.555	1.351-1.792	<0.001	1.716	1.453-2.027	<0.001
T4	1.974	1.726-2.258	<0.001	2.303	1.970-2.692	<0.001
N stage
N0	Reference			Reference
N1	0.76	0.666-0.867	<0.001	0.803	0.686-0.939	0.006
N2	0.876	0.767-0.999	0.049	0.997	0.855-1.163	0.970
N3	1.284	1.093-1.509	0.002	1.536	1.280-1.844	<0.001
M stage
M0	Reference			Reference
M1	3.182	2.756-3.676	<0.001	3.905	3.353-4.549	<0.001
Chemotherapy
Yes	Reference			Reference
No/unknown	1.312	1.144-1.505	<0.001	1.207	1.026-1.421	<0.001