Nomogram to Predict Long-Term Overall Survival and Cancer-Specific Survival of Radiotherapy Patients with Nasopharyngeal Carcinoma

Table 3

Multivariate Cox regression analysis of overall survival and cancer-specific survival in nasopharyngeal carcinoma in the training cohort.

Variables	Overall survival			Cancer-specific survival
	HR	95% CI		HR	95% CI
Total
Age group (years)
<50	Reference			Reference
50-64	1.835	1.601-2.103	<0.001	1.652	1.422-1.920	<0.001
≥65	3.327	2.866-3.863	<0.001	2.513	2.120-2.979	<0.001
Race
Black	Reference			Reference
White	0.946	0.809-1.107	0.488	0.879	0.735-1.051	0.158
Asian/Pacific islander	0.737	0.620-0.875	<0.001	0.781	0.644-0.948	0.012
Indian/Alaska native	1.411	0.978-2.034	0.065	1.399	0.923-2.120	0.114
Marital status
Single	Reference			Reference
Married	0.866	0.754-0.993	0.040	0.894	0.765-1.045	0.160
Divorced	1.282	1.065-1.544	0.009	1.279	1.033-1.584	0.024
Windowed/separated	1.406	1.143-1.729	0.001	1.376	1.079-1.753	0.009
Histology
KSCC	Reference			Reference
DNKC	0.715	0.619-0.824	<0.001	0.718	0.611-0.844	<0.001
UNKC	0.629	0.512-0.775	<0.001	0.583	0.457-0.742	<0.001
Others	0.920	0.804-1.054	0.229	0.870	0.745-1.017	0.081
Grade
Well	Reference			Reference
Moderate	0.911	0.635-1.306	0.612	0.915	0.599-1.398	0.682
Poor	0.794	0.565-1.116	0.184	0.794	0.532-1.185	0.259
Undifferentiated	0.759	0.529-1.088	0.133	0.735	0.481-1.123	0.154
Unknown	0.819	0.581-1.156	0.257	0.794	0.530-1.189	0.263
Tumor size (cm)
<3	Reference			Reference
3-5	1.281	1.084-1.514	0.004	1.268	1.041-1.544	0.018
>5	1.667	1.368-2.031	<0.001	1.751	1.398-2.194	<0.001
Unknown	1.482	1.270-1.728	<0.001	1.523	1.270-1.827	<0.001
AJCC stage
I	Reference			Reference
II	1.378	1.038-1.828	0.026	1.612	1.118-2.324	0.011
III	1.74	1.292-2.344	<0.001	2.577	1.772-3.747	<0.001
IV	1.632	1.165-2.287	0.004	2.508	1.668-3.771	<0.001
T stage
T1	Reference			Reference
T2	1.045	0.891-1.225	0.589	1.097	0.912-1.319	0.327
T3	1.218	1.013-1.465	0.036	1.146	0.931-1.411	0.198
T4	1.611	1.281-2.025	<0.001	1.528	1.193-1.957	<0.001
N stage
N0	Reference			Reference
N1	0.899	0.770-1.051	0.182	0.918	0.767-1.099	0.351
N2	0.925	0.785-1.091	0.356	0.892	0.740-1.076	0.232
N3	1.368	1.089-1.717	0.007	1.34	1.047-1.716	0.020
M stage
M0	Reference			Reference
M1	2.926	2.437-3.512	<0.001	3.278	2.701-3.978	<0.001
Chemotherapy
Yes	Reference			Reference
No/unknown	1.488	1.274-1.738	<0.001	1.593	1.328-1.911	<0.001