Drug Discovery in Canine Pyometra Disease Identified by Text Mining and Microarray Data Analysis

Figure 4

The drugs targeted to genes and their functional enrichment analysis. (a) Chord plot for the connection between 23 drugs and 8 genes; (b) chord plot for functional enrichments of 8 genes. GO: gene ontology; BP: biological process; CC: cellular component; MF: molecular function; KEGG: Kyoto Encyclopedia of Genes and Genomes. GO-BP (1) indicates immune response, GO-BP (2) indicates the cell surface receptor signaling pathway, GO-BP (3) indicates the T cell receptor signaling pathway, GO term-CC indicates cytosol, GO-MF (1) indicates signal transducer activity, GO-MF (2) indicates cytokine receptor activity, GO-MF (3) indicates phosphatidylinositol phosphate binding, KEGG (1) indicates leukocyte transendothelial migration, KEGG (2) indicates osteoclast differentiation, and KEGG (3) indicates primary immunodeficiency.

(a)

(b)