Drug Discovery in Canine Pyometra Disease Identified by Text Mining and Microarray Data Analysis

Table 1

The 256 differentially expressed genes were identified between TMGs and DEGs (GSE99877), including 70 upregulated genes and 186 downregulated genes in dog uterus with pyometra samples compared to control dog uterus samples. (The differentially expressed genes were ranked from the smallest to the largest of adjusted value).

DEGs	Genes
Upregulated	DGKI, SPTLC3, FREM2, CNTLN, DACH1, MPPED2, SNCAIP, FAIM2, ZMAT4, TNFRSF19, PLEKHA5, TMOD2, PAQR5, FGF9, MATN2, HECTD2, TMEM55A, ABI3BP, OSR2, RYR3, STOX1, FAM149A, PRELP, PRKD1, EFEMP1, NFIX, ANK2, FZD3, SESTD1, ABCA9, OGN, RPS6KA6, RWDD3, SPAG16, BCL9, DDIT4L, OPHN1, NTRK3, LRCH2, NDP, FRMPD4, MYRIP, EFHC2, PDE11A, PTCH1, RUNDC3B, NAALADL2, PTGIS, CACHD1, NEGR1, RBP1, HMGCLL1, GABRA3, KLHL32, RASSF6, LGR5, ECHDC2, GDA, ZNF521, RCAN2, GCLC, MAMDC2, SLC2A12, EPHA7, ASPA, ANGPTL1, AUTS2, KCNN3, ATRNL1, and ANK3
Downregulated	NCKAP1L, SLC46A3, LRMP, GGH, KLHL6, BCAT1, FAR2, TPX2, SLC26A4, RGS2, OLFML2B, RND1, KIF11, SLC39A14, MYBL2, LOXL2, STK17A, SLAMF7, LCP1, ESCO2, CD48, PIK3AP1, TRAF3IP3, ARHGDIB, IKZF1, PIK3CG, DKK2, FAM20A, ST3GAL1, SLC16A6, TNIP3, RGS1, NCF2, CECR1, AOAH, GNG2, DAPP1, EDEM1, LPXN, PTPRE, IRF4, CLEC5A, EDIL3, SEMA7A, BTG2, PLAC8, GIMAP6, NID2, ABCG1, PDK1, ADAM28, BHLHA15, SPI1, BPI, SDC1, TFEC, LCP2, LAT2, SELL, DDX43, RAB27B, PRKCB, INPP5D, FFAR2, FCGBP, CCR2, PLCG2, CHI3L1, TFPI2, EVI2B, CDH3, ATP8B4, GMFG, IKZF3, SLCO2B1, SAMSN1, SLC16A3, CD37, P2RY13, ARHGAP15, INHBB, TKT, RHOH, KMO, CSF2RA, TNFSF13B, MALL, CASC5, RNASE6, SLC1A5, TMEM150B, ATP13A4, TYROBP, IRF8, ASF1B, C6, CYTH4, CAPN14, COTL1, SBNO2, CD3D, ARPC1B, CKAP2L, PTPRC, HCLS1, LY9, STEAP4, PFKP, CD180, SLAMF6, CD79B, SLC43A2, PFKFB3, IGSF6, BUB1, LAPTM5, GNA15, FAM78A, THBS4, AIF1, EHD3, SERPINB10, SLC2A9, ATP1B3, DOCK2, SMPDL3A, NDUFA4L2, CPM, CTSH, TNFAIP3, TNFRSF17, LRRC25, TOP2A, CPA3, XDH, SRGN, IGFBP5, DDIT4, CD53, ACOXL, CDA, JAK3, S100A12, S100A9, CSF2RB, SLC6A14, DHRS9, TBX20, SERPINE2, SPN, CAPG, PRC1, SOD2, ST6GALNAC4, SLC16A7, NCAPG, NCF4, TMEM45B, BTK, IL10RA, LOC608320, ADAP2, CSF1R, LDLR, HK2, FABP3, ITGAL, SLC1A4, PCOLCE, FAM46C, FYB, GLIPR1, VAV1, EMB, POU2AF1, BCL3, TNFSF11, FERMT3, GPR183, FMNL1, TAGAP, TLR8, PLCB2, DOCK10, PLXNC1, and EGLN3