Drug Discovery in Canine Pyometra Disease Identified by Text Mining and Microarray Data Analysis

Table 2

The top three gene ontology and pathway enrichment terms of upregulated and downregulated genes, respectively.

Terms	Category	Description	Count	value
Upregulated genes
GO:0072661	BP	Protein targeting to plasma membrane	3	0.002285
GO:0043583	BP	Ear development	5	0.005787
GO:0007423	BP	Sensory organ development	7	0.007154
GO:0031012	CC	Extracellular matrix	7	0.001358
GO:0045202	CC	Synapse	7	0.003773
GO:0043197	CC	Dendritic spine	3	0.007865
GO:0008201	MF	Heparin binding	4	0.003801
GO:0005539	MF	Glycosaminoglycan binding	4	0.009789
GO:0030507	MF	Spectrin binding	2	0.010964
cfa05205	KEGG	Proteoglycans in cancer	4	0.037887
Downregulated genes
GO:0006955	BP	Immune response	41	4.12E-16
GO:0045321	BP	Leukocyte activation	30	5.74E-13
GO:0001775	BP	Cell activation	32	7.49E-13
GO:0044421	CC	Extracellular region part	58	5.52E-06
GO:1903561	CC	Extracellular vesicle	47	1.26E-05
GO:0043230	CC	Extracellular organelle	47	1.28E-05
GO:0005342	MF	Organic acid transmembrane transporter activity	7	6.97E-04
GO:0008047	MF	Enzyme activator activity	11	0.002017
GO:0046943	MF	Carboxylic acid transmembrane transporter activity	6	0.003604
cfa04662	KEGG	B cell receptor signaling pathway	8	3.67E-05
cfa04380	KEGG	Osteoclast differentiation	10	5.64E-05
cfa04666	KEGG	Fc gamma R-mediated phagocytosis	8	1.43E-04

Note: GO: gene ontology; BP: biological process; CC: cellular components; MF: molecular function; KEGG: Kyoto Encyclopedia of Genes and Genomes.