Drug Discovery in Canine Pyometra Disease Identified by Text Mining and Microarray Data Analysis

Table 4

The functional enrichments of the final 8 genes.

Category	ID	Term	Genes	p-value
GO-BP	GO:0006955	Immune response	PTPRC, BTK, PLCG2, and ITGAL	0.000932
GO-BP	GO:0007166	Cell surface receptor signaling pathway	PTPRC, BTK, PLCG2, and ITGAL	0.007812
GO-BP	GO:0050852	T cell receptor signaling pathway	PTPRC and PLCG2	0.017121
GO-CC	GO:0005829	Cytosol	NCF4, BTK, and PLCG2	0.056613
GO-MF	GO:0004871	Signal transducer activity	PLCG2, CSF2RB, ITGAL, and CSF2RA	0.045474
GO-MF	GO:0004896	Cytokine receptor activity	CSF2RB and CSF2RA	0.04673
GO-MF	GO:1901981	Phosphatidylinositol phosphate binding	NCF4 and BTK	0.054916
KEGG pathway	cfa04670	Leukocyte transendothelial migration	NCF4, PLCG2, and ITGAL	0.004198
KEGG pathway	cfa04380	Osteoclast differentiation	NCF4, BTK, and PLCG2	0.005013
KEGG pathway	cfa05340	Primary immunodeficiency	PTPRC and BTK	0.030721

Note: GO: gene ontology; BP: biological process; CC: cellular components; MF: molecular function; KEGG: Kyoto Encyclopedia of Genes and Genomes.