ATR Inhibitor Synergizes PARP Inhibitor Cytotoxicity in Homologous Recombination Repair Deficiency TK6 Cell Lines

Figure 1

ATR inhibition facilitates the cell cycle progression of cells containing PARP inhibitor-induced DNA damage. The proportion of cells in G1, S, and G2/M of the cell cycle of indicated genotypes exposed to PARP inhibitor ((a) olaparib, (b) talazoparib, and (c) veliparib) and/or AZD6738. Averages and standard deviations of three independent experiments are displayed. The statistical difference of proportions of cells in G2/M phases between PARP inhibitor with and without AZD6738 treatments within the same genotype was calculated using Student’s -test. ; ; ; .

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