ATR Inhibitor Synergizes PARP Inhibitor Cytotoxicity in Homologous Recombination Repair Deficiency TK6 Cell Lines

Figure 3

The combination of PARP and ATR inhibitors increases an amount of DNA damage in mitotic cells. A number of gH2AX foci per mitotic nucleus of indicated genotypes treated with PARP inhibitor ((a) olaparib, (b) talazoparib, and (c) veliparib) and/or AZD6738 are shown. Black lines indicate medians. The statistical difference of a number of gH2AX foci per mitotic nucleus between treatments within the same genotype was calculated using the Mann-Whitney test. ; ; ; .

(a)

(b)

(c)